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KMID : 1039220190290040508
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Journal of Korean Society of Occupational and Environmental Hygiene
2019 Volume.29 No. 4 p.508 ~ p.516
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Acute toxicity study of the glyoxal by intratracheal instillation in male Sprague-Dawley rats
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Kim Hyeon-Young
Kim Ki-Cheon
Kim In-Hyeon
Kim Min-Seok
Kim Sung-Hwan
Lee Kyu-Hong
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Abstract
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Objectives: The present study was performed to obtain acute toxicity information on glyoxal in male rats after intratracheal instillation.
Methods: In order to calculate the LD50 of glyoxal using Probit analysis with SAS, the test article was one intratracheal instillation to male Sprague-Dawley rats at dose levels of 0, 225, 451 or 902 mg/kg. During the test period, mortality, clinical signs, and body and organ weights were examined. At the end of the 14-day observation period, all animals were sacrificed and complete gross postmortem and histopathological examinations were performed.
Results: Four animals of the 902 mg/kg group died within one week after the administration of glyoxal. All treatment group in a dose dependent manner, decreased body weight was found during the study period. The absolute and relative lung weight, and histopathological changes (bronchiolar-alveolar hyperplasia, chronic inflammation) of lung exhibited an increased in glyoxal treated groups in a dose dependent manner. However, there were no changes on the organ weights and histopathological changes of any other organ except lung.
Conclusions: The results obtained in the present study suggest that the LD50 in male Sprague-Dawley rats after a single intratracheal instillation of glyoxal was considered to be 866.9 mg/kg and the lung was found to be the target organ for glyoxal.
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KEYWORD
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acute toxicity, glyoxal, intratracheal instillation, LD50, pulmonary toxicity
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